abstract：:The distinction between partial hydatidiform mole (PHM) and trisomy gestation is not always straightforward histologically and it is unclear which morphological features, alone or in combination, provide the greatest diagnostic accuracy. We performed a comparative review of 89 products of conception (POC) specimens in...

journal_title：Pathology

authors： Wilson Y,Bharat C,Crook ML,Kee AR,Peverall J,Ruba S,Stewart CJ

更新日期：2016-10-01 00:00:00

abstract：:Recently developed antibodies against uroplakin II and ΔNp63 (p40) show utility in diagnosing primary bladder urothelial carcinoma, although application in metastatic bladder cancer and patient outcomes has been less well defined. We evaluated these antibodies by immunostain intensity and H-score, in conjunction with ...

journal_title：Pathology

authors： Leivo MZ,Elson PJ,Tacha DE,Delahunt B,Hansel DE

更新日期：2016-10-01 00:00:00

abstract：:The monitoring of infliximab drug levels aids in the management of several autoimmune diseases, notably inflammatory bowel disease. Several commercial kits are now available and approved by the Therapeutic Goods Administration (TGA) for the measurement of infliximab levels, but there have been limited verification or ...

journal_title：Pathology

authors： Lee MW,Connor S,Ng W,Toong CM

更新日期：2016-10-01 00:00:00

abstract：:Atypical teratoid/rhabdoid tumours (AT/RTs) are rare, highly malignant tumours of the central nervous system (CNS) with poor prognosis that usually affect young children. The aim of this study was to assess the clinicopathological features and prognostic factors of AT/RTs. Here, we describe the clinicopathological and...

journal_title：Pathology

authors： Wang RF,Guan WB,Yan Y,Jiang B,Ma J,Jiang MW,Wang LF

更新日期：2016-10-01 00:00:00

abstract：:We aimed to evaluate the diagnostic utility of the novel immunohistochemical marker TROP-2 on thyroid specimens (226 tumours and 207 controls). Whole slide immunohistochemistry was performed and scored by automated digital image analysis. Non-neoplastic thyroid, follicular adenomas, follicular carcinomas, and medullar...

journal_title：Pathology

authors： Bychkov A,Sampatanukul P,Shuangshoti S,Keelawat S

更新日期：2016-08-01 00:00:00

abstract：:The objective of this study was to establish a population based reference range for a commercial immunoblot assay detecting myositis specific autoantibodies (MSAs) and myositis associated autoantibodies (MAAs), and to assess the diagnostic performance of this reference range against the manufacturer's recommended rang...

journal_title：Pathology

authors： Bundell C,Rojana-Udomsart A,Mastaglia F,Hollingsworth P,McLean-Tooke A

更新日期：2016-06-01 00:00:00

abstract：:The dense fine speckled (DFS) pattern is an antinuclear antibody (ANA) pattern that has recently become of interest. This particular pattern has not been associated with systemic autoimmune rheumatic disorders (SARD) but has been associated with other inflammatory conditions such as interstitial nephritis, autoimmune ...

journal_title：Pathology

authors： Broadfoot A,Sivertsen T,Baumgart K

更新日期：2016-04-01 00:00:00

abstract：:The field of systemic cancer therapy for metastatic disease has entered an exciting era with the advent of novel immunomodulatory strategies targeting immune checkpoints. At the heart of these promising efforts are the tumour-infiltrating lymphocytes (TILs). As the reports demonstrating efficacy of modulating TIL effe...

journal_title：Pathology

authors： Lee N,Zakka LR,Mihm MC Jr,Schatton T

更新日期：2016-02-01 00:00:00

abstract：:The application of glucose point of care testing (PoCT) in hospitals has been a contentious subject for many years. No information is available regarding the extent to which glucose PoCT is used within the Australian hospital system and whether such testing is fit for its intended purpose. The aim of this study was to...

journal_title：Pathology

authors： Sharp L,Farrance I,Greaves RF

更新日期：2016-01-01 00:00:00

abstract：:The aims of this study were to investigate the immunohistochemical expression and potential prognostic significance of putative cancer stems cell markers ALDH1, EZH2 and SOX2 in prostate cancer.A total of 142 consecutive radical prostatectomies submitted to one laboratory with a diagnosis of prostatic adenocarcinoma b...

journal_title：Pathology

authors： Matsika A,Srinivasan B,Day C,Mader SA,Kiernan DM,Broomfield A,Fu J,Hooper JD,Kench JG,Samaratunga H

更新日期：2015-12-01 00:00:00

abstract：:Tumour infiltrating lymphocytes in primary melanoma have been found to correlate with patient outcomes. A subpopulation of tumour infiltrating lymphocytes expresses the transcription factor forkhead box protein 3 (FOXP3). These are known as FOXP3+ T-regulatory cells (Tregs) and are thought to play an immune suppressiv...

journal_title：Pathology

authors： Leslie C,Bowyer SE,White A,Grieu-Iacopetta F,Trevenen M,Iacopetta B,Amanuel B,Millward M

更新日期：2015-10-01 00:00:00

abstract：:A novel grading system based on the counting of poorly differentiated clusters (PDC) of neoplastic cells at the invasive margin and in the tumour stroma was recently introduced among the histological parameters predictive of adverse clinical outcome in colorectal cancer (CRC). The aim of this study was to correlate th...

journal_title：Pathology

authors： Barresi V,Bonetti LR,Bettelli S

更新日期：2015-10-01 00:00:00

abstract：:The 2005 International Society of Urological Pathology (ISUP) modified Gleason grading system was further amended in 2014 with the establishment of grade groupings (ISUP grading). This study examined the predictive value of ISUP grading, comparing results with recognised prognostic parameters.Of 3700 men undergoing ra...

journal_title：Pathology

authors： Samaratunga H,Delahunt B,Gianduzzo T,Coughlin G,Duffy D,LeFevre I,Johannsen S,Egevad L,Yaxley J

更新日期：2015-10-01 00:00:00

abstract：:Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack ...

journal_title：Pathology

authors： Smith DW,Rawlinson WD,Kok J,Dwyer DE,Catton M

更新日期：2015-08-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) is currently regarded as a myeloid neoplasm, with remarkably broad clinical spectrum, ranging from isolated skin or bone lesions to a disseminated disease that can involve nearly any organ. LCH is generally regarded as a sporadic disease that occurs predominantly in the paediatric p...

journal_title：Pathology

authors： El Demellawy D,Young JL,de Nanassy J,Chernetsova E,Nasr A

更新日期：2015-06-01 00:00:00

abstract：:Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleu...

journal_title：Pathology

authors： Son SM,Han HS,An JY,Choe KH,Lee KM,Lee KH,Kim SS,Lee YM,Lee HC,Song HG,Lee OJ

更新日期：2015-02-01 00:00:00

abstract：:IgG4 related disease (IgG4RD) is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. Although rare, mammary involvement has been reported as IgG4...

journal_title：Pathology

authors： Chougule A,Bal A,Das A,Singh G

更新日期：2015-01-01 00:00:00

abstract：:There are few studies addressing survival of diffuse peritoneal mesotheliomas (DPM).In this study, survival data were obtained retrospectively from 73 patients treated with intended cytoreductive surgery for DPM, with a mean follow-up of 42 months. Mesotheliomas were classified as well differentiated papillary (WDPM, ...

journal_title：Pathology

authors： Liu S,Staats P,Lee M,Alexander HR,Burke AP

更新日期：2014-12-01 00:00:00

abstract：:Micropapillary carcinoma of the colon and rectum is associated with an adverse prognosis. This tumour type displays reverse polarity of the tumour cells and is stated to be characterised by an inside-out epithelial membrane antigen (EMA)/MUC1 staining. Nine cases of primary colorectal carcinoma and one omental metasta...

journal_title：Pathology

authors： Cserni G

更新日期：2014-10-01 00:00:00

abstract：:Renal cell carcinoma (RCC) generally has a poor prognosis because of late diagnosis and metastasis. We have previously described decreased tumour necrosis factor receptor-associated factor-1 (TRAF-1) in RCC compared with paired normal kidney in a patient cohort in Australia. In the present study, TRAF-1 expression in ...

journal_title：Pathology

authors： Rajandram R,Yap NY,Pailoor J,Razack AH,Ng KL,Ong TA,Morais C,Gobe GC

更新日期：2014-10-01 00:00:00

abstract：:The most common of all activating BRAF mutations (T1799A) leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The major goal of this study was to compare detection of the BRAF V600E mutation by DNA sequencing with immunohistochemistry (IHC) using the anti-BRAF V60...

journal_title：Pathology

authors： Dvorak K,Aggeler B,Palting J,McKelvie P,Ruszkiewicz A,Waring P

更新日期：2014-10-01 00:00:00

abstract：:The aim of the present study is to describe the histological and mutational characteristics of a series of both large and small bowel adenocarcinomas in patients with Crohn's disease from a tertiary referral centre of inflammatory bowel disease. Bowel adenocarcinoma was diagnosed in 11 (1.7%) of 660 consecutive patien...

journal_title：Pathology

authors： Malvi D,Vasuri F,Mattioli B,Gruppioni E,Fiorentino M,Gionchetti P,Grigioni WF,Poggioli G,D'Errico-Grigioni A

更新日期：2014-08-01 00:00:00

abstract：:The BRAF(V600E) mutation confers worse prognosis to metastatic colorectal cancer (mCRC) patients. In addition, this mutation has a negative predictive value for response to treatment with monoclonal antibodies against EGFR in patients with KRAS wild-type (wt) mCRC. The utility of immunohistochemistry (IHC) as an alter...

journal_title：Pathology

authors： Ilie MI,Long-Mira E,Hofman V,Mouroux J,Vignaud JM,Gauchotte G,Begueret H,Merlio JP,Emile JF,Hébuterne X,Hofman P

更新日期：2014-06-01 00:00:00

abstract：:Age-specific paediatric reference intervals are used in interpretation of laboratory results. However, interpretation may be problematic when a child just crosses an age bracket and the difference between the original and the subsequent age-specific reference interval is large. Moreover, details about the physiologica...

journal_title：Pathology

authors： Loh TP,Antoniou G,Baghurst P,Metz MP

更新日期：2014-06-01 00:00:00

abstract：:Soft tissue tumours represent a heterogeneous group of mesenchymal lesions and their classification continues to evolve as a result of incorporating advances in cytogenetic and molecular techniques. In the last decade, traditional diagnostic approaches were supplemented with a significant number of reliable molecular ...

journal_title：Pathology

authors： Antonescu CR,Dal Cin P

更新日期：2014-02-01 00:00:00

abstract：AIMS:BRAF mutation has been shown in a large meta-analysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and higher recurrence rates. METHODS:We studied prevalence of BRAF mutation in 77 patients with PTC from an Australian cohort using competitive polymerase chain r...

journal_title：Pathology

authors： McKelvie PA,Chan F,Yu Y,Waring P,Gresshoff I,Farrell S,Williams RA

更新日期：2013-12-01 00:00:00

abstract：AIMS:Biochemical analysis of glucose and ketones in the vitreous humour obtained at post-mortem examination is representative of the levels in the blood prior to death. Elevated levels can be indicative of conditions including diabetic ketoacidosis, which can be a cause for unexpected death. A rapid screening test for ...

journal_title：Pathology

authors： Mitchell R,Thomas SD,Langlois NE

更新日期：2013-10-01 00:00:00

abstract：AIMS:To investigate the evolutionary origins of Australian healthcare-associated (HCA) methicillin-resistant Staphylococcus aureus (MRSA) strains from a panel of historical isolates typed using current genotyping techniques. METHODS:Nineteen MRSA isolates from 1965 to 1981 were examined and antibiotic susceptibility p...

journal_title：Pathology

authors： Lancashire JF,Jones A,Bergh H,Huygens F,Nimmo GR

更新日期：2013-08-01 00:00:00

abstract：:Understanding human genetic variation and how it impacts on gene function is a major focus in genomic-based research. Translation of this knowledge into clinical care is exemplified by pharmacogenetics/pharmacogenomics. The identification of particular gene variants that might influence drug uptake, metabolism, distri...

journal_title：Pathology

authors： Trent RJ,Cheong PL,Chua EW,Kennedy MA

更新日期：2013-06-01 00:00:00

abstract：:The ultimate goal of defining cancer specific precursors is to facilitate early detection and intervention before the development of invasive malignancy. Unlike other malignancies involving the female genital tract such as cervical or endometrial carcinomas, precursor lesions of ovarian carcinomas have not been well c...

journal_title：Pathology

authors： Lim D,Oliva E

更新日期：2013-04-01 00:00:00

abstract：:Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these pat...

journal_title：Pathology

authors： Samaratunga H,Martignoni G,Egevad L,Delahunt B

更新日期：2013-04-01 00:00:00

abstract：:BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumour suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutat...

journal_title：Pathology

authors： Murali R,Wiesner T,Scolyer RA

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously. AIMS:To document the clinical and histopathological findings in a series of patients with DPA. RESULTS:Of the 8 patients identi...

journal_title：Pathology

authors： Scolyer RA,Karim RZ,Thompson JF,Stretch JR,McCarthy SW,Murali R

更新日期：2013-01-01 00:00:00

abstract：AIMS:Clinical decision making and optimal clinical trial design based on cancer genetic information will be increasingly informed by the mutational status of multiple genes. METHODS:We performed mutation screening on 22 fresh frozen gastrointestinal stromal tumours (GISTs) using a multiplexed oncogene screening panel ...

journal_title：Pathology

authors： Kang G,Lee J,Jang KT,Beadling C,Corless CL,Heinrich MC,Park JO,Kang WK,Park CK,Kim KM

更新日期：2012-08-01 00:00:00

abstract：AIMS:CD151 belongs to the group of tetraspanins and is aberrantly expressed in different tumours and differential expression has been associated with prognosis. The aim of this study was to clarify the relationship of CD151 expression with tumour phenotype and clinical outcome in bladder cancer. METHODS:A bladder canc...

journal_title：Pathology

authors： Minner S,De Silva C,Rink M,Dahlem R,Chun F,Fisch M,Höppner W,Wagner W,Bokemeyer C,Terracciano L,Simon R,Sauter G,Wilczak W

更新日期：2012-08-01 00:00:00

abstract：AIMS:We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome. METHODS:Clinicopathological data were obtained from 140 cases of triple negative breast cancer. A t...

journal_title：Pathology

authors： De Brot M,Rocha RM,Soares FA,Gobbi H

更新日期：2012-06-01 00:00:00

abstract：AIMS:The aim of the study was to evaluate the role of Serpin B3/B4 in advanced idiopathic pulmonary fibrosis (IPF) patients, mainly focusing on epithelial proliferation. METHODS:Lungs from 48 IPF patients (including cases with cancer or high-grade epithelial dysplasia) were studied and compared with other diffuse pare...

journal_title：Pathology

authors： Calabrese F,Lunardi F,Balestro E,Marulli G,Perissinotto E,Loy M,Nannini N,Valente M,Saetta M,Agostini C,Rea F

更新日期：2012-04-01 00:00:00

abstract：AIMS:The increasing importance of cardiac disease has generated an interest in improved screening strategies regarding preclinical cardiac abnormalities and employing measurement of circulating biomarkers. This review focuses on the utility of the B-type natriuretic peptides (NP) and the cardiac troponins (cTns) for th...

journal_title：Pathology

authors： Eggers KM,Venge P

更新日期：2012-02-01 00:00:00

abstract：AIMS:In our previous studies, comparative proteomics demonstrated that lactate dehydrogenase B subunit (LDH-B) is down-regulated in high grade compared to non-high grade urinary bladder urothelial carcinoma (UBUC). However, this finding has not been validated by clinical cohort investigation. Therefore, in the present ...

journal_title：Pathology

authors： Liao AC,Li CF,Shen KH,Chien LH,Huang HY,Wu TF

更新日期：2011-12-01 00:00:00

abstract：AIMS:Activation of β-catenin has been identified as a possible mechanism for the development of nephroblastomas. In our study we investigated whether this activation occurs already in precursor lesions of nephroblastomas, called nephrogenic rests (NRs). Inactivation of the adenomatous polyposis coli (APC) protein is an...

journal_title：Pathology

authors： Grill C,Sunitsch S,Hatz M,Hauser-Kronberger C,Leuschner I,Hoefler G,Guertl B

更新日期：2011-12-01 00:00:00